MCQ in chemotherapy

MCQ in chemotherapy

MCQ with explanation (Raj K. Prasad)

 

1. During administration ofketoconazole we should avoid
   1.   Ranitidine
   2.   Antacids
   3.   Amphotericin-B
   4.   All ofthe above
2. Metronidazole is selectively active against anaerobes because:
   1.   Aerobes have an active transport system topump it outof their cell.
   2.   It is rapidly inactivated in thepresence of oxygen.
   3.   It binds to DNA ofanaerobes with high affinity.
   4.   Anaerobes reduce its nitro group to generate the reactive radical.
3. Which one ofthe following statements about diloxanide is incorrect:
   1.   Contraindicated in pregnancy& children
   2.   First choice luminal amebicide
   3.   90% unabsorbed orally
   4.   Eradicates the amebic cysts
4. Ganciclovir is preferred over acyclovir in the following condition:
   1.   Chickenpox.
   2.   Herpes simplex.
   3.   Herpes zoster.
   4.   Cytomegalovirus retinitis inAIDS patients
5. Risk of teratogenecity is least with
   1.   Flubendazole
   2.   Bleomycin
   3.   Mebendazole
   4.   Thiabendazole
6. An antimicrobial that is better to be avoided in patients with myasthenia gravis?
   1.   Gentamycin.
   2.   Rifampicin
   3.   Tetracycline.
   4.   Ampicillin.
7. The main reason for the limited use of chloramphenicol is high incidence of:
   1.   Aplastic anemia.
   2.   Hepatotoxicity.
   3.   Interstitial nephritis.
   4.   Pulmonary fibrosis
8. Aprimarily bacteriostatic antibiotic that is bactericidal at high concentrations is
   1.   Erythromycin.
   2.   Tetracycline.
   3.   Ethambutol.
   4.   Ampicillin.
9. Concerning clindamycin, the following are true EXCEPT:
   1.   Binds to 50 S- subunit and inhibits translocation reaction
   2.   Effective in bone infection
   3.   Effective against staph & anaerobic bacteria
   4.   Effective mainly against gram -ve bacteria
10. Currently the drug ofchoice for empiric treatment oftyphoid fever is:
    1.   Chlorammhenicol.
    2.   Ampicillin.
    3.   Ciprofloxacin.
    4.   Co-trimoxazole.
11. The following is not a concentration -dependent antibiotic:
    1.   Gentamycin
    2.   Ciprofloxacin
    3.   Erythromycin
    4.   Azithromycin
12. The following is not a time-dependentantibiotic:
    1.   Vancomycin
    2.   Cephalosporins
    3.   Penicillins
    4.   Quinolones
13. The following is/are excreted renally
    1.   Penicillin.
    2.   Vancomycin
    3.   Cefazolin
    4.   Allof the above
14. Avoid with dairy products or antacids
    1.   Ciprofloxacin
    2.   Erythromycin.
    3.   Fluconazole
    4.   All of the above
15. The following is not excreted through bile
    1.   Doxycycline
    2.   Amikacin.
    3.   Rifampicin
    4.   Doxycycline
16. During administration ofketoconazole we should avoid
    1.   Ranitidine
    2.   C. Antacids
    3.   Amphotericin-B
    4.   D. All ofthe above