MCQ-3 Medicinal Chemistry (Practice set)

MCQ-3 in Medicinal chemistry (with explanation)

MCQ with explanation (Raj K. Prasad)

  

 

1. Which one UREIDOPENICILLINS
   1.   Talampicillin
   2.   Ticarcillin
   3.   Piperacillin
   4.   Azidocillin
2. What stereoisomerism exists between quinine and quinidine? They are:
   1.   enantiomers
   2.   diastereomers
   3.   tautomers
   4.   epimers
3. Which of the following statements is correct for chloroquine?
   1.   It is an aminoquinoline derivative.
   2.   It contains two nitrogens.
   3.   The aromatic ring carries two chlorine atom substituents.
   4.   The aromatic ring carries two
      chlorine atom substituents.
4. Which of the following statements is correct for tetracyclines?
   1.   They contain only alcoholic hydroxyl groups.
   2.   They contain a quaternary nitrogen.
   3.   They have an amphoteric character.
   4.   They contain a free carboxyl group.
5. Which of the following statements is correct for chloramphenicol?
   1.   It contains a 1,2-aminoalcohol moiety.
   2.   Both of its nitrogens are basic.
   3.   It has cis or trans isomers.
   4.   It contains one alcoholic
      hydroxyl group.
6. Which of the following chemotherapeutics contains a hydroxyethyl side chain?
   1.   nalidixic acid
   2.   furazolidone
   3.   metronidazole
   4.   nitrofurantoin
7. From which of the heterocycles listed below can cycloserine be derived?
   1.   oxazole
   2.   oxazolidine
   3.   isoxazolidine
   4.   morpholine
8. What structure do the sulfonamides mimic when acting as enzyme inhibitors?
   1.   Dihydropteroate
   2.   Para-aminosulfonic acid
   3.   L-glutamic acid
   4.   Para-aminobenzoic acid
9. Which of the following is the general mechanism of action for vancomycin?
   1.   Inhibition of a metabolic enzyme.
   2.   Inhibition of cell wall synthesis.
   3.   Disruption of protein synthesis.
   4.   Inhibition of nucleic acid transcription and replication.
10. Which of the following drugs does not act against cell wall synthesis?
    1.   Vancomycin
    2.   Chloramphenicol
    3.   Penicillins
    4.   Cycloserine
11. Which of the following drugs acts as an intercalator?
    1.   Valinomycin
    2.   Proflavine
    3.   Sulfathiazole
    4.   Methacillin
12. Proflavine contain which ring?
    1.   Piperidine
    2.   Piperazine
    3.   Pyrimidine
    4.   Acridine
13. Which statement is false regarding the fluoroquinoline antibacterial agents?
    1.   They inhibit transcription
    2.   They target enzymes called helicases
    3.   They inhibit replication
    4.   They stabilise an enzyme-DNAdrug complex where four fluoroquinoline molecules are stacked together.
14. Sulfasalazine is a combination of:
    1.   sulfapyridine, 5-aminosalicylic acid
    2.   Sulfamethoxazole, trimethoprim
    3.   Sulfadoxine , pyrimethamine
    4.   Sulfadiazine , dapson.
15. Which of the following is neuramedase inhibitor?
    1.   Zanamivan
    2.   Palivizumab
    3.   Enfuvirtide
    4.   Maraviroc